TLR3

TLR3
Structures disponibles PDB Recherche d'orthologue: PDBe RCSB Identifiants PDB 1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA
Identifiants
Aliases	TLR3, CD283
IDs externes	OMIM: 603029 MGI: 2156367 HomoloGene: 20696 GeneCards: TLR3
Position du gène (Homme) Chr. Chromosome 4 humain[1] Locus 4q35.1 Début 186,069,155 bp[1] Fin 186,088,073 bp[1]
Position du gène (Souris) Chr. Chromosome 8 (souris)[2] Locus 8|8 B1.1 Début 45,848,702 bp[2] Fin 45,864,117 bp[2]
Expression génétique Bgee Humain Souris (orthologue) Fortement exprimé dans muqueuse jéjunale palpebral conjunctiva placenta rectum sperme duodénum vésicule biliaire tendon calcanéen epithelium of colon pancreatic epithelial cell Fortement exprimé dans conjunctival fornix gastrula strie vasculaire transitional epithelium of urinary bladder vestibular membrane of cochlear duct vestibular sensory epithelium secondary oocyte lumbar subsegment of spinal cord Epithelium of choroid plexus Jéjunum Plus de données d'expression de référence BioGPS Plus de données d'expression de référence
Gene Ontology Fonction moléculaire liaison protéique identical protein binding liaison ARN liaison ARN double brin transmembrane signaling receptor activity signaling receptor activity Composant cellulaire cytoplasme integral component of membrane endosome membrane du réticulum endoplasmique membrane Golgi membrane integral component of plasma membrane intracellulaire surface cellulaire lysosomal membrane early endosome réticulum endoplasmique endolysosome membrane endosome membrane milieu extracellulaire matrice extracellulaire Processus biologique positive regulation of interferon-beta production response to dsRNA réponse de défense positive regulation of toll-like receptor signaling pathway positive regulation of protein phosphorylation male gonad development positive regulation of inflammatory response positive regulation of interleukin-12 production positive regulation of type III interferon production cellular response to interferon-beta response to exogenous dsRNA negative regulation of osteoclast differentiation positive regulation of cytokine production processus du système immunitaire response to virus activation of NF-kappaB-inducing kinase activity I-kappaB phosphorylation positive regulation of JNK cascade hyperosmotic response cellular response to dsRNA regulation of dendritic cell cytokine production microglial cell activation toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway cellular response to mechanical stimulus microglial cell activation involved in immune response positive regulation of gene expression defense response to bacterium positive regulation of NF-kappaB transcription factor activity defense response to virus necroptotic signaling pathway positive regulation of interleukin-8 production cellular response to exogenous dsRNA positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production cellular response to interferon-gamma positive regulation of chemokine production positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling detection of virus réponse inflammatoire système immunitaire inné I-kappaB kinase/NF-kappaB signaling toll-like receptor 3 signaling pathway positive regulation of type I interferon production MyD88-independent toll-like receptor signaling pathway transduction de signal positive regulation of transcription by RNA polymerase II Nécrose programmée apoptotic signaling pathway negative regulation of MyD88-independent toll-like receptor signaling pathway extrinsic apoptotic signaling pathway positive regulation of angiogenesis positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 7098 142980 Ensembl ENSG00000164342 ENSMUSG00000031639 UniProt O15455 Q99MB1 RefSeq (mRNA) NM_003265 NM_126166 NM_001357316 NM_001357317 RefSeq (protéine) NP_003256 NP_569054 NP_001344245 NP_001344246 Localisation (UCSC) Chr 4: 186.07 – 186.09 Mb Chr 8: 45.85 – 45.86 Mb Publication PubMed [3] [4]
Wikidata
Voir/Editer Humain Voir/Editer Souris

Le TLR3 (ou CD283) est une protéine de type récepteur de type Toll intervenant dans l'immunité inné. Il s'agit également d'une cluster de différenciation. Son gène est le TLR3 situé sur le chromosome 4 humain.